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Paclitaxel-d5

Names

[ CAS No. ]:
1129540-33-5

[ Name ]:
Paclitaxel-d5

Biological Activity

[Description]:

Paclitaxel D5 is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9.

[2]. Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₇H₄₆D₅NO₁₄

[ Molecular Weight ]:
858.93700

[ Exact Mass ]:
858.36200

[ PSA ]:
224.78000

[ LogP ]:
4.31050

Related Compounds