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2’-O-Methyl-2-thiouridine

Names

[ CAS No. ]:
113886-72-9

[ Name ]:
2’-O-Methyl-2-thiouridine

[Synonym ]:
s2Um
2'-O-methyl-2-thiouridine
2’-O-methyl-2-thiouridine
1-(2-O-methyl-β-D-ribofuranosyl)-2-thio-4-(1H,3H)-pyrimidinone
1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Biological Activity

[Description]:

2’-O-Methyl-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H14N2O5S

[ Molecular Weight ]:
274.29

[ Exact Mass ]:
274.06200

[ PSA ]:
128.80000

Related Compounds