n-methylbis(indol-3-yl)maleimide

Names

[ Name ]:
n-methylbis(indol-3-yl)maleimide

[Synonym ]:
Ro 31-6045
2,3-bis(1H-Indol-3-yl)-N-methylmaleimide
MFCD00236433
3,4-Di(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione
bisindolylmaleimide v
3,4-bis(3-indolyl)-1-methyl-pyrrole-2,5-dione
1-Methyl-3,4-bis(3-indolyl)maleimide
1H-Pyrrole-2,5-dione,3,4-di-1H-indol-3-yl-1-methyl
1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-1-methyl-
n-methylbis(indol-3-yl)maleimide

Biological Activity

[Description]:

Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)

[References]

[1]. Lazareno S, et al. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol. 1998 Nov 6;360(2-3):281-4.

[2]. Marmy-Conus N, et al. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling. FEBS Lett. 2002 May 22;519(1-3):135-40.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
655.7±55.0 °C at 760 mmHg

[ Melting Point ]:
271°C

[ Molecular Formula ]:
C₂₁H₁₅N₃O₂

[ Molecular Weight ]:
341.363

[ Flash Point ]:
350.3±31.5 °C

[ Exact Mass ]:
341.116425

[ PSA ]:
68.96000

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.794

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%