2-chloro-3'-deoxyadenosine

Names

[ Name ]:
2-chloro-3'-deoxyadenosine

[Synonym ]:
biodribin
C10H14ClN5O3
Adenosine,2-chloro-3'-deoxy
2-Chloro-3'-deoxyadenosine
2-chlorocordycepin
3'-Deoxy-2-chloroadenosine
UNII-JYW18Y92UP

Biological Activity

[Description]:

2-Chloro-3′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.03g/cm3

[ Boiling Point ]:
547.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₂ClN₅O₃

[ Molecular Weight ]:
285.69

[ Flash Point ]:
285ºC

[ Exact Mass ]:
285.06300

[ PSA ]:
119.31000

[ LogP ]:
0.28380

[ Vapour Pressure ]:
7.95E-13mmHg at 25°C

[ Index of Refraction ]:
1.87

2-chloro-3'-deoxyadenosine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds