B2

Names

[ Name ]:
B2

[Synonym ]:
CPNQ
BP 554 maleate
5-[4-(4-chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline B2
B2
(4-Chlorophenyl)[4-(8-Nitro-5-Quinolinyl)-1-Piperazinyl]Methanone

Biological Activity

[Description]:

SIRT2-IN-8 is a potent SIRT2 inhibitor. SIRT2-IN-8 can be used for Huntington’s and Parkinson’s diseases research[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Research Areas >> Neurological Disease

[Target]

SIRT2

[References]

[1]. Bodner RA, Outeiro TF, Altmann S, et al. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proc Natl Acad Sci U S A. 2006;103(11):4246-4251.

Chemical & Physical Properties

[ Density]:
1.4±0.1g/cm3

[ Boiling Point ]:
645.5±55.0°C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₇ClN₄O₃

[ Molecular Weight ]:
396.83

[ Flash Point ]:
344.2±31.5°C

[ Exact Mass ]:
396.09900

[ PSA ]:
82.26000

[ LogP ]:
4.28490

[ Appearance of Characters ]:
solid brown

[ Index of Refraction ]:
1.687

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Soluble to 100 mM in DMSO and to 10 mM in ethanol

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
25-36/37/38

[ Safety Phrases ]:
26-45

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ WGK Germany ]:
3

Articles

Physicochemical characterisation of four cherry species (Prunus spp.) grown in China.

Food Chem. 173 , 855-63, (2014)

The physicochemical characteristics of four cherry species (Prunus avium, Prunus cerasus, Prunus pseudocerasus and Prunus tomentosa) were evaluated. Inter-species variability was greater than intra-sp...

The B vitamins nicotinamide (B3) and riboflavin (B2) stimulate metamorphosis in larvae of the deposit-feeding polychaete Capitella teleta: implications for a sensory ligand-gated ion channel.

PLoS ONE 9(11) , e109535, (2014)

Marine sediments can contain B vitamins, presumably incorporated from settled, decaying phytoplankton and microorganisms associated with decomposition. Because B vitamins may be advantageous for the e...

Vibration mechanosignals superimposed to resistive exercise result in baseline skeletal muscle transcriptome profiles following chronic disuse in bed rest.

Sci. Rep. 5 , 17027, (2015)

Disuse-induced muscle atrophy is a major concern in aging, in neuromuscular diseases, post-traumatic injury and in microgravity life sciences affecting health and fitness also of crew members in space...

B2