CI 972 (anhydrous)
Names
Biological Activity
[Description]:
CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2].
[Related Catalog]:
[Target]
Ki: 0.83 μM (PNP)[1]
[In Vivo]
CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats[1].
[References]
Chemical & Physical Properties
[ Boiling Point ]:
602.2ºC at 760mmHg
[ Molecular Formula ]:
C11H12ClN5OS
[ Molecular Weight ]:
297.76400
[ Flash Point ]:
318ºC
[ Exact Mass ]:
297.04500
[ PSA ]:
142.55000
[ LogP ]:
2.38120
[ Vapour Pressure ]:
1.87E-14mmHg at 25°C
Safety Information
[ Hazard Codes ]:
Xi