SR 3576

Names

[ CAS No. ]:
1164153-22-3

[ Name ]:
SR 3576

[Synonym ]:
SR-3576
Aminopyrazole inhibitor,3576

Biological Activity

[Description]:

SR-3576 is a highly potent and selective JNK3 inhibitor with an IC50 of 7 nM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> MAPK/ERK Pathway >> JNK

[Target]

JNK3:7 nM (IC50)

[References]

[1]. Kamenecka T, et al. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284(19):12853-61.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₇N₅O₅

[ Molecular Weight ]:
501.53400

[ Exact Mass ]:
501.20100

[ PSA ]:
122.72000

[ LogP ]:
5.57340

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38.

J. Biol. Chem. 19th ed., 284 , 12853-12861, (2009)

c-Jun N-terminal kinase 3alpha1 (JNK3alpha1) is a mitogen-activated protein kinase family member expressed primarily in the brain that phosphorylates protein transcription factors, including c-Jun and...