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STO-609 (acetate)

Names

[ CAS No. ]:
1173022-21-3

[ Name ]:
STO-609 (acetate)

[Synonym ]:
7-Oxo-7H-benzimidazo[2,1-a]benzo[de]isoquinoline-3-carboxylic acid acetate (1:1)
7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-, acetate (1:1)

Biological Activity

[Description]:

STO-609 acetate is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 acetate inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Signaling Pathways >> Neuronal Signaling >> CaMK
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Research Areas >> Metabolic Disease

[References]

[1]. Tokumitsu H, et al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8.  

[2]. Kukimoto-Niino M, et al. Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H14N2O5

[ Molecular Weight ]:
374.35

[ Exact Mass ]:
374.090271

[ PSA ]:
108.97000

[ LogP ]:
3.38100

Related Compounds