Pradimicin A

Names

[ Name ]:
Pradimicin A

Biological Activity

[Description]:

Pradimicin A (PRM-A) is a potent antifungal agent, with an MIC of 4 μg/mL against Candida rugosa. Pradimicin A has antiviral activities against CoV, HIV and other enveloped viruses. Pradimicin A shows aggregation property, and can recognize d-Man in the presence of Ca2+ ion[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

MIC: 4 μg/mL (Candida rugosa)[1]

[References]

[1]. Miyanishi W, et al. d-Mannose binding, aggregation property, and antifungal activity of amide derivatives of pradimicin A. Bioorg Med Chem. 2021 Dec 27;55:116590.

[2]. Nakagawa Y, Doi T, Masuda Y, Takegoshi K, Igarashi Y, Ito Y. Mapping of the primary mannose binding site of pradimicin A. J Am Chem Soc. 2011 Nov 2;133(43):17485-93.

Chemical & Physical Properties

[ Density]:
1.688g/cm3

[ Boiling Point ]:
1120.269°C at 760 mmHg

[ Molecular Formula ]:
C₄₀H₄₄N₂O₁₈

[ Molecular Weight ]:
840.78

[ Flash Point ]:
631.316°C

[ Exact Mass ]:
840.25900

[ PSA ]:
320.56000

[ LogP ]:
0.17010

Pradimicin A

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds