4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine

Names

[ Name ]:
4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine

[Synonym ]:
1H-Pyrazolo[3,4-d]pyrimidine-4,6-diamine, 1-(2-deoxy-α-D-erythro-pentofuranosyl)-
1-(2-Deoxy-α-D-erythro-pentofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Biological Activity

[Description]:

4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Galmarini CM, et al. Pyrimidine nucleoside analogs in cancer treatment. Expert Rev Anticancer Ther. 2003 Oct;3(5):717-28.

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
717.7±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆N₆O₃

[ Molecular Weight ]:
268.27

[ Flash Point ]:
387.8±35.7 °C

[ Exact Mass ]:
266.112732

[ LogP ]:
-1.50

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.936