Pyrindamycin A

Names

[ Name ]:
Pyrindamycin A

[Synonym ]:
duocarmycin C2
Pyrindamycin A

Biological Activity

[Description]:

Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC50 of 3.9 μg/ml[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. Ishii S, et al. Antitumor activity of pyrindamycins A and B. J Antibiot (Tokyo). 1989 Nov;42(11):1713-7.

Chemical & Physical Properties

[ Density]:
1.433g/cm3

[ Boiling Point ]:
767ºC at 760mmHg

[ Molecular Formula ]:
C₂₆H₂₆ClN₃O₈

[ Molecular Weight ]:
543.95300

[ Flash Point ]:
417.7ºC

[ Exact Mass ]:
543.14100

[ PSA ]:
139.42000

[ LogP ]:
3.62500

[ Vapour Pressure ]:
2.28E-24mmHg at 25°C

[ Index of Refraction ]:
1.643

Pyrindamycin A

Names

Biological Activity

Chemical & Physical Properties

Related Compounds