Galanin (human) acetate salt

Names

[ CAS No. ]:
119418-04-1

[ Name ]:
Galanin (human) acetate salt

[Synonym ]:
MFCD00135986
Galanin,Human
Galanin-1-30
Galanin (1-30), human

Biological Activity

[Description]:

Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

Peptides

Research Areas >> Neurological Disease

[Target]

Kd: 1 nM (GalR1 receptor), 1 nM (GalR2 receptor)[2]

[In Vitro]

Galanin (1-30), human (Gal1-30) is an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM[1]. Galanin (1-30), human displaces 125I-labeled rat galanin with a Kd of 0.5 nM. Galanin (1-30), human (hGal) causes contractions of isolated longitudinal rat fundus strips, with an ED50 of 13.8 ± 1.6 nM[2].

[References]

[1]. Hua XY, et al. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 2004 Feb;308(2):574-82.

[2]. Schmidt WE, et al. Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11435-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃₉H₂₁₀N₄₂O₄₃

[ Molecular Weight ]:
3157.41000

[ Exact Mass ]:
3155.55000

[ PSA ]:
1367.68000

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

The Influence of Low Doses of Zearalenone on Distribution of Selected Active Substances in Nerve Fibers Within the Circular Muscle Layer of Porcine Ileum.

J. Mol. Neurosci. 56(4) , 878-86, (2015)

The aim of this study was to investigate, whether low doses (25 % of no observable adverse effect levels values) of zearalenone (ZEN) can affect the expression of active substances in nerve fibers in ...

Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer.

Oncol. Rep. 33(2) , 539-46, (2015)

Reliable predictors of tumor recurrence for patients with stage II colorectal cancer (CRC) are needed to select patients who should receive adjuvant chemotherapy. Although galanin (GAL) is expressed i...

Association of galanin and major depressive disorder in the Chinese Han population.

PLoS ONE 8(5) , e64617, (2013)

This study aimed to investigate the association of galanin (GAL) gene and the development of depression in the Chinese Han population.A total of 700 patients with depression who met the diagnostic cri...