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NITD-2

Names

[ CAS No. ]:
1197896-79-9

[ Name ]:
NITD-2

Biological Activity

[Description]:

NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

NITD-2 inhibits de novo RNA synthesis[1]. NITD-2 exhibited no antiviral activity in cell culture resulted from the poor cell penetratration[1].

[References]

[1]. Pornwaratt Niyomrattanakit, et al. Inhibition of dengue virus polymerase by blocking of the RNA tunnel. J Virol. 2010 Jun;84(11):5678-86.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H19N3O4S

[ Molecular Weight ]:
433.48

Safety Information

[ Hazard Codes ]:
Xi


Related Compounds