SIRT-IN-3

Names

[ Name ]:
SIRT-IN-3

[Synonym ]:
N-phenyl-anthranilic acid amide
Benzamide,o-anilino
N-Phenyl-anthranilsaeure-amid
Anilinobenzamide
N-phenylanthranylamide
N-phenylanthranilamide

Biological Activity

[Description]:

SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[In Vitro]

SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells[1].

[References]

[1]. Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1(10):1059-62.

Chemical & Physical Properties

[ Density]:
1.218g/cm3

[ Boiling Point ]:
413.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₂N₂O

[ Molecular Weight ]:
212.24700

[ Flash Point ]:
203.8ºC

[ Exact Mass ]:
212.09500

[ PSA ]:
55.12000

[ LogP ]:
3.30240

[ Vapour Pressure ]:
4.84E-07mmHg at 25°C

[ Index of Refraction ]:
1.663

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV2340485

CHEMICAL NAME :: Benzamide, o-anilino-

CAS REGISTRY NUMBER :: 1211-19-4

BEILSTEIN REFERENCE NO. :: 0782669

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H12-N2-O

MOLECULAR WEIGHT :: 212.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - ataxia Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 60,703,1971

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%