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Iprodione-d5

Names

[ CAS No. ]:
1215631-57-4

[ Name ]:
Iprodione-d5

[Synonym ]:
3-[3,5-Dichloro(H)phenyl]-N-isopropyl-2,4-dioxo(H)imidazolidine-1-carboxamide
1-Imidazolidine-5,5-d-carboxamide, 3-(3,5-dichlorophenyl-2,4,6-d)-N-(1-methylethyl)-2,4-dioxo-
3-[3,5-Dichloro(H)phenyl]-N-isopropyl-2,4-dioxo-1-(H)imidazolidinecarboxamide

Biological Activity

[Description]:

Iprodione-d5 is the deuterium labeled Iprodione[1]. Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective[2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Radice S, et al. Effect of iprodione, a dicarboximide fungicide, on primary cultured rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol. 2001;54(1-2):51-58.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C13H8D5Cl2N3O3

[ Molecular Weight ]:
335.197

[ Exact Mass ]:
334.064789

[ LogP ]:
2.80

[ Index of Refraction ]:
1.604

Related Compounds