Pacritinib hydrochloride
Names
[ CAS No. ]:
1228923-43-0
[ Name ]:
Pacritinib hydrochloride
Biological Activity
[Description]:
Pacritinib hydrochloride is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib hydrochloride also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Pacritinib hydrochloride can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF)[1][2][3].
[Related Catalog]:
[Target]
JAK2V617F:19 nM (IC50)
JAK3:520 nM (IC50)
JAK1:1280 nM (IC50)
JAK2wt:23 nM (IC50)
Tyk2:50 nM (IC50)
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C28H32N4O3.xClH