ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate

Names

[ Name ]:
ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate

[Synonym ]:
2-(4-methoxy-phenyl)-5-methyl-oxazole-4-carboxylic acid ethyl ester
ethyl 5-methyl-2-(4-methoxy)phenyl-4-oxazolecarboxylate
2-(4-Methoxyphenyl)-4-carbethoxy-5-methyloxazole

Biological Activity

[Description]:

Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

Anticancer agent 73 (compound CIB-3b) (10 μM; 6 hours) increases the expression of E-cadherin and decreases the protein expression levels of fibronectin, N-cadherin, and vimentin in SK-HEP-1 cells; inhibits the proliferation and migration of SK-HEP-1, HCCLM3 and MHCC97L cells by inhibiting miRNA biogenesis[1].

[In Vivo]

Anticancer agent 73 (10, 25 and 50 mg/kg; IV, every 2 days for 4 weeks) attenuates the proliferation and migration of SK-HEP-1 and SK-HEP-1 implanted in SCID mice[1]

[References]

[1]. Peng T, et al. Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. J Med Chem. 2022 Jun 13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₅NO₄

[ Molecular Weight ]:
261.27300

[ Exact Mass ]:
261.10000

[ PSA ]:
61.56000

[ LogP ]:
2.83530