syringomycin E

Names

[ Name ]:
syringomycin E

[Synonym ]:
SYRINGOMYCIN E FROM PSEUDOMONAS SYRINGAE B-301D
syringomycin-E

Biological Activity

[Description]:

Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K+ efflux, Ca2+ influx, and changes in membrane potential, and is related to channel formation[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Syringomycin E (0.5 μg/mL, 1 μg/mL; 48 h) 对酿酒酵母菌株 SS33 和 SS56 有抑制作用[1]。 Syringomycin E 是一种离子通道型，对电势跨膜分布的变化敏感[2]。

[References]

[1]. Stock SD, et al. Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Antimicrob Agents Chemother. 2000 May;44(5):1174-80.

[2]. Efimova SS, et al. Alkaloids Modulate the Functioning of Ion Channels Produced by Antimicrobial Agents via an Influence on the Lipid Host. Front Cell Dev Biol. 2020 Jun 30;8:537.

Chemical & Physical Properties

[ Density]:
1.47g/cm3

[ Molecular Formula ]:
C₅₃H₈₅ClN₁₄O₁₇

[ Molecular Weight ]:
1225.78000

[ Exact Mass ]:
1224.59000

[ PSA ]:
522.86000

[ LogP ]:
0.18720

[ Index of Refraction ]:
1.641

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

Articles

Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae.

FEMS Microbiol. Lett. 358(1) , 64-71, (2014)

Syringomycin E is a cyclic lipodepsipeptide produced by strains of the plant bacterium Pseudomonas syringae pv. syringae. Genetic studies involving the yeast Saccharomyces cerevisiae have revealed tha...

Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels.

Langmuir 23(13) , 6889-92, (2007)

We evaluated the effect of agents modifying the membrane dipole potential: phloretin, 6-ketocholestanol and RH 421 on the properties of single channels formed by lipodepsipeptide syringomycin E (SRE) ...

[Transport of large organic ions through syringomycin channels in the membranes containing dipole modifiers].

Tsitologiia 53(5) , 450-6, (2011)

The effect of the membrane dipole potential (Phid) on a conductance and a steady-state number of functioning channels formed by cyclic lipodepsipeptide syringomycin E (SRE) in bilayer lipid membranes ...