Compound 7

Names

[ CAS No. ]:
1252003-13-6

[ Name ]:
Compound 7

Biological Activity

[Description]:

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

pIC50: 7.2 (HDAC6), and 6.8 (HDAC10)[1]

[In Vitro]

HDAC-IN-4 inhibits HDAC1, HDAC2, HDAC3, HDAC8 and HDAC10 with pIC50s of 5.5, 4.6, 5.4, 5.4, 6.7 in FRET assay, respectively[1]. HDAC-IN-4 is more potent against HDAC6 than Tubastatin A, suggests that HDAC-IN-4 may be a better HDAC6 probe than Tubastatin A[1].

[References]

[1]. Géraldy M, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019 May 9;62(9):4426-4443.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₁N₃O₂

[ Molecular Weight ]:
335.40

Compound 7

Names

Biological Activity

Chemical & Physical Properties

Related Compounds