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Regorafenib D3

Names

[ CAS No. ]:
1255386-16-3

[ Name ]:
Regorafenib D3

[Synonym ]:
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-(methyl-d3)-2-pyridinecarboxamide

Biological Activity

[Description]:

Regorafenib D3 (BAY 73-4506 D3) is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> MAPK/ERK Pathway >> Raf
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[References]

[1]. Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H12D3ClF4N4O3

[ Molecular Weight ]:
485.83400

[ Exact Mass ]:
485.09600

[ PSA ]:
92.35000

[ LogP ]:
6.22570

Related Compounds