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NU5455

Names

[ CAS No. ]:
1257235-99-6

[ Name ]:
NU5455

Biological Activity

[Description]:

NU5455 is a potent, selective, and orally active inhibitor of DNA-PKcs. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK
Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK

[References]

[1]. Willoughby CE, et al. Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy. J Clin Invest. 2020;130(1):258-271.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H33N3O5S

[ Molecular Weight ]:
595.71

Related Compounds