RO495

Names

[ Name ]:
RO495

[Synonym ]:
Benzamide, N-[2-[(2-amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichloro-
N-{2-[(2-Amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl}-2,6-dichlorobenzamide
RO495

Biological Activity

[Description]:

RO495 is a potent inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2 kinase)[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[Target]

TYK2

[References]

[1]. Tobie D. Lee, et al. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology November 2019, 96 (5) 629-640.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₁₄Cl₂N₆O

[ Molecular Weight ]:
389.24

[ Exact Mass ]:
388.060608

[ LogP ]:
4.36

[ Index of Refraction ]:
1.739

[ Storage condition ]:
-20°C