Oxethazaine

Names

[ CAS No. ]:
126-27-2

[ Name ]:
Oxethazaine

[Synonym ]:
2,2'-[(2-Hydroxyethyl)imino]bis[N-methyl-N-(2-methyl-1-phenyl-2-propanyl)acetamide]
2,2'-[(2-hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methylacetamide]
Acetamide, 2,2'-[(2-hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methyl-
N,N-Bis[N-methyl-N-phenyl-tert-butylacetamido]-b-hydroxyethylamine
EINECS 204-780-5
2,2'-[(2-Hydroxyethyl)imino]bis[N-methyl-N-(2-methyl-1-phenylpropan-2-yl)acetamide]
MFCD00079202
2-[2-hydroxyethyl-[2-[methyl-(2-methyl-1-phenylpropan-2-yl)amino]-2-oxoethyl]amino]-N-methyl-N-(2-methyl-1-phenylpropan-2-yl)acetamide
oxethazine
2,2'-[(2-Hydroxyethyl)imino]bis[N(1,1-dimethyl-2-phenylethyl)-N-methylacetamide]

Biological Activity

[Description]:

Oxethazaine is a topical anesthetic, in preventing acid-induced esophageal pain.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HBV

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
630.4±55.0 °C at 760 mmHg

[ Melting Point ]:
104-105°C

[ Molecular Formula ]:
C₂₈H₄₁N₃O₃

[ Molecular Weight ]:
467.643

[ Flash Point ]:
335.1±31.5 °C

[ Exact Mass ]:
467.314789

[ PSA ]:
64.09000

[ LogP ]:
4.94

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.558

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
<0.1 g/100 mL at 23 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC3325000

CHEMICAL NAME :: Acetamide, 2,2'-((2-hydroxyethyl)imino)bis(N-(alpha,alpha-dimeth ylphenethyl)-N-methyl-

CAS REGISTRY NUMBER :: 126-27-2

BEILSTEIN REFERENCE NO. :: 2404063

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C28-H41-N3-O3

MOLECULAR WEIGHT :: 467.72

WISWESSER LINE NOTATION :: R1X1&1&N1&V1N2Q1VN1&X1&1&1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Mold - Aspergillus nidulans

DOSE/DURATION :: 1 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82267 No. of Facilities: 838 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 29119 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82267 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1056 (estimated) No. of Female Employees: 490 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AC3325000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Oxethazaine as the source of mephentermine and phentermine in athlete's urine

Forensic Sci. Int. 185(1-3) , e1-5, (2009)

The urine specimens of numerous athletes were found to be positive for mephentermine both in-competition and out-of-competition in Taiwan. The donor of one specimen claimed she had only taken Mucaine ...

Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis.

J. Anal. Toxicol. 34(2) , 73-7, (2010)

Mephentermine and phentermine, substances prohibited in sports by the World Anti-Doping Agency, were found for the first time in urine specimens following the administration of a therapeutic medicatio...

A double-blind controlled study to compare the efficacy of an antacid plus oxethazaine with that of an antacid alone in the treatment of pain due to gastric or duodenal ulceration.

Curr. Med. Res. Opin. 10(2) , 128-34, (1986)

A double-blind study was carried out in 40 patients with typical ulcer pain and suffering from gastric or duodenal ulcer to compare the pain-relieving efficacy of oxethazaine/magnesium and aluminium h...