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S6K-18

Names

[ CAS No. ]:
1265789-88-5

[ Name ]:
S6K-18

[Synonym ]:
2-[(1H-Indazol-5-ylcarbamoyl)amino]-5-(2-methyl-2-propanyl)-3-thiophenecarboxylic acid
3-Thiophenecarboxylic acid, 5-(1,1-dimethylethyl)-2-[[(1H-indazol-5-ylamino)carbonyl]amino]-
S6K-18

Biological Activity

[Description]:

S6K-18 is a potent and selective p70S6K1 inhibitor with an IC50 of 52 nM[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)

[Target]

S6K1:52 nM (IC50)


[References]

[1]. Ye P, et al. Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg Med Chem Lett. 2011 Jan 15;21(2):849-52.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
494.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H18N4O3S

[ Molecular Weight ]:
358.41

[ Flash Point ]:
253.1±28.7 °C

[ Exact Mass ]:
358.109955

[ PSA ]:
135.35000

[ LogP ]:
5.22

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.746

Related Compounds