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Basifungin

Names

[ CAS No. ]:
127785-64-2

[ Name ]:
Basifungin

[Synonym ]:
aurantoside B

Biological Activity

[Description]:

Aureobasidin A (Basifungin), a cyclic depsipetide, is an antifungal antibiotic. Aureobasidin A (Basifungin) A is an inhibitor of the inositolphosphorylceramide synthase AUR1[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Inflammation/Immunology

[In Vitro]

Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides[2].

[References]

[1]. K Ikai, et al. Structure of aureobasidin A. J Antibiot (Tokyo). 1991 Sep;44(9):925-33.

[2]. Vanessa Cerantola, et al. Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Mol Microbiol. 2009 Mar;71(6):1523-37.

[3]. K Kino, et al. Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins. FEBS Lett. 1996 Dec 9;399(1-2):29-32.

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
1229.1ºC at 760 mmHg

[ Molecular Formula ]:
C60H92N8O11

[ Molecular Weight ]:
1101.42000

[ Flash Point ]:
697.1ºC

[ Exact Mass ]:
1100.69000

[ PSA ]:
245.85000

[ LogP ]:
4.88900

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.574

Related Compounds