DPQ

Names

[ Name ]:
DPQ

[Synonym ]:
5-[4-(1-Piperidinyl)-butyloxy]-1,2,3,4-tetrahydroisoquinolin-1-one
5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one
1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-
5-[4-(1-Piperidinyl)butoxy]-3,4-dihydro-1(2H)-isoquinolinone
5-[4-(Piperidin-1-yl)butoxy]-3,4-dihydroisoquinolin-1(2H)-one

Biological Activity

[Description]:

DPQ is a potent PARP-1 inhibitor. DPQ can reduce the N-methyl-d-aspartate (NMDA)-induced PARP activation, restoring ATP to near control levels and significantly attenuating neuronal injury in the severe NMDA exposure model. DPQ can be used for researching neuroprotection[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PARP

Research Areas >> Neurological Disease

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP-1[1]

[References]

[1]. Meli E, et al. Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Mol Cell Neurosci. 2004;25(1):172-180.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
528.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₆N₂O₂

[ Molecular Weight ]:
302.41

[ Flash Point ]:
273.6±30.1 °C

[ Exact Mass ]:
302.199432

[ PSA ]:
41.57000

[ LogP ]:
2.25

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.544

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

Articles

DNA Double Strand Break Response and Limited Repair Capacity in Mouse Elongated Spermatids.

Int. J. Mol. Sci. 16 , 29923-35, (2015)

Spermatids are extremely sensitive to genotoxic exposures since during spermiogenesis only error-prone non homologous end joining (NHEJ) repair pathways are available. Hence, genomic damage may accumu...

Parp1-XRCC1 and the repair of DNA double strand breaks in mouse round spermatids.

Mol. Cell. 683 , 84-90, (2010)

The repair of DNA double strand breaks (DSBs) in male germ cells is slower and differently regulated compared to that in somatic cells. Round spermatids show DSB repair and are radioresistant to apopt...

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

Nat. Med. 3 , 1089, (1997)

Nitric oxide (NO) and peroxynitrite, formed from NO and superoxide anion, have been implicated as mediators of neuronal damage following focal ischemia, but their molecular targets have not been defin...

DPQ