Cytarabine triphosphate

Names

[ Name ]:
Cytarabine triphosphate

Biological Activity

[Description]:

Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. Anderson E, et, al. Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia. Exp Hematol. 2019 Jun;74:13-18.e3.

Chemical & Physical Properties

[ Density]:
2.5g/cm3

[ Boiling Point ]:
849.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₈N₃O₁₃P₃

[ Molecular Weight ]:
481.18400

[ Flash Point ]:
467.4ºC

[ Exact Mass ]:
481.00500

[ PSA ]:
291.61000

[ Index of Refraction ]:
1.638

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5590000

CHEMICAL NAME :: Cytosine, 1-beta-D-arabinofuranosyl-, 5'-(tetrahydrogen triphosphate)

CAS REGISTRY NUMBER :: 13191-15-6

LAST UPDATED :: 199109

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H16-N3-O14-P3

MOLECULAR WEIGHT :: 483.19

WISWESSER LINE NOTATION :: T6NVNJ DZ A- BT5OTJ BOPQQO COPQQO D1OPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 100 umol/L

REFERENCE :: BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 425,1,1976