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4-Amino-1-pentofuranosyl-2(1H)-pyrimidinethione

Names

[ CAS No. ]:
13239-97-9

[ Name ]:
4-Amino-1-pentofuranosyl-2(1H)-pyrimidinethione

[Synonym ]:
4-Amino-1-pentofuranosyl-2(1H)-pyrimidinethione
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2-thione
2-Thiocytidin
EINECS 236-214-8
2-Thiocytidine
2(1H)-Pyrimidinethione, 4-amino-1-pentofuranosyl-
MFCD00167106
Cytidine,2-thio

Biological Activity

[Description]:

2-Thiocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
540.5±60.0 °C at 760 mmHg

[ Melting Point ]:
208-209 °C (lit.)

[ Molecular Formula ]:
C9H13N3O4S

[ Molecular Weight ]:
259.28

[ Flash Point ]:
280.7±32.9 °C

[ Exact Mass ]:
259.062683

[ PSA ]:
145.85000

[ LogP ]:
-1.33

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.788

Related Compounds