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10-Vinyl-19-norpregn-4-ene-3,20-dione

Names

[ CAS No. ]:
13258-85-0

[ Name ]:
10-Vinyl-19-norpregn-4-ene-3,20-dione

[Synonym ]:
19-Methylen-progestron
(8S,9S,10S,13S,14S,17S)-17-Acetyl-13-methyl-10-vinyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
10-ethenyl-19-norprogesterone

Biological Activity

[Description]:

Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Progesterone Receptor
Research Areas >> Endocrinology
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

[Target]

33.9 nM (mPRα)[1]


[References]

[1]. Kelder J, et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids. 2010 Apr;75(4-5):314-22.  

[2]. Camilletti MA, et al. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. J Neuroendocrinol. 2018 Sep;30(9):e12614.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H30O2

[ Molecular Weight ]:
326.47200

[ Exact Mass ]:
326.22500

[ PSA ]:
34.14000

[ LogP ]:
4.88960

Related Compounds