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Tolnaftate-d7

Names

[ CAS No. ]:
1329835-64-4

[ Name ]:
Tolnaftate-d7

[Synonym ]:
Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl-d7 ester
Tolnaftate-d7
O-(2H7)-2-Naphthyl methyl(3-methylphenyl)carbamothioate

Biological Activity

[Description]:

Tolnaftate D7 (NP-27 D7) is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60.

[3]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
453.4±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H10D7NOS

[ Molecular Weight ]:
314.453

[ Flash Point ]:
228.0±26.8 °C

[ Exact Mass ]:
314.147034

[ LogP ]:
5.15

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.697

Related Compounds