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KFM19

Names

[ CAS No. ]:
133058-72-7

[ Name ]:
KFM19

[Synonym ]:
(+,-)-8-(3-oxocyclopentyl)-1,3-dipropylxanthine
8-(3-oxocyclopentyl)-1,3-di-n-propyl-7H-purine-2,6-dione
Biip 20
1,3-dipropyl-8-(3-oxocyclopentyl)-xanthine
((S)-(-)-8-(3-Oxocyclopentyl)-1,3-dipropyl-7H-purine-2,6-dione)
Kfm 19
8-(3-Oxo-cyclopentyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
KFM19

Biological Activity

[Description]:

KFM19 is a potent, selective Adenosine receptor (A1-receptor) antagonist, with an IC50 of 50 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Research Areas >> Neurological Disease

[Target]

IC50: 50 nM (Adenosine receptor)[1]


[References]

[1]. W.D. Bechtel, et al. KFM 19 antagonizes the adenosine-induced inhibition of electrically evoked acetylcholine release. Eur Neuropsychopharmacol. Sep. 1993, 3(3), Page 433


[Related Small Molecules]

CGS 21680 hydrochloride | Preladenant | ZM 241385 | CPI-444 | SCH 58261 | Vipadenant | Istradefylline | Tozadenant | AZD-4635 | Capadenoson | 2-CL-IB-MECA | PSB-12379 | CD73-IN-1 | IB-MECA | Diprophylline

Chemical & Physical Properties

[ Density]:
1.268g/cm3

[ Boiling Point ]:
584.7ºC at 760mmHg

[ Molecular Formula ]:
C16H22N4O3

[ Molecular Weight ]:
318.37100

[ Flash Point ]:
307.4ºC

[ Exact Mass ]:
318.16900

[ PSA ]:
89.75000

[ LogP ]:
1.54290

[ Vapour Pressure ]:
1.18E-13mmHg at 25°C

[ Index of Refraction ]:
1.575

[ Storage condition ]:
2-8℃

Related Compounds