5-(6-amino-8-methylamino-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

Names

[ Name ]:
5-(6-amino-8-methylamino-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

[Synonym ]:
9-(2-deoxypentofuranosyl)-n8-methyl-9h-purine-6,8-diamine
8-methylamino-2'-deoxy-adenosine

Biological Activity

[Description]:

2'-Deoxy-8-methylamino-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.85g/cm3

[ Boiling Point ]:
634.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₆N₆O₃

[ Molecular Weight ]:
280.28

[ Flash Point ]:
337.5ºC

[ Exact Mass ]:
280.12800

[ PSA ]:
131.34000

[ Vapour Pressure ]:
5.72E-17mmHg at 25°C

[ Index of Refraction ]:
1.836