10-formylfolic acid (25 mg)

Names

[ CAS No. ]:
134-05-4

[ Name ]:
10-formylfolic acid (25 mg)

[Synonym ]:
10-Formylpteroylglutamic Acid
10-Formylfolic acid
N10-Formylfolic Acid

Biological Activity

[Description]:

10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate

[References]

[1]. M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9.

[2]. J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8.

Chemical & Physical Properties

[ Density]:
1.67g/cm3

[ Molecular Formula ]:
C₂₀H₁₉N₇O₇

[ Molecular Weight ]:
469.40800

[ Exact Mass ]:
469.13500

[ PSA ]:
221.56000

[ LogP ]:
1.11410

[ Index of Refraction ]:
1.748

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays.

J. Agric. Food Chem. 50(17) , 4760-8, (2002)

[2H4]Folic acid was synthesized by deuterating p-aminobenzoic acid, which was then coupled to glutamic acid and 6-formylpterin. Using [2H4]folic acid as starting component enabled the preparation of l...

Folate metabolism in man: the effect of malignant disease.

Br. J. Cancer 46(3) , 346-53, (1982)

The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding inclu...

Applicability of alkyl-bonded ultra-pure silica stationary phases for gradient reversed-phase HPLC of folates with conventional and volatile buffers under highly aqueous conditions.

J. Sep. Sci. 29(6) , 889-904, (2006)

Applicability of several alkyl-bonded silica stationary phases was tested for gradient RP-HPLC of folates under highly aqueous conditions. High retention of folates was achieved on alternative phases ...