9-(2'-O-Acetyl-5'-O-benzoyl-3'-deoxy-beta-D-ribofuranosyl)-6-chloropurine

Names

[ CAS No. ]:
1347118-41-5

[ Name ]:
9-(2'-O-Acetyl-5'-O-benzoyl-3'-deoxy-beta-D-ribofuranosyl)-6-chloropurine

[Synonym ]:
9-(2-O-Acetyl-5-O-benzoyl-3-deoxy-β-D-erythro-pentofuranosyl)-6-chloro-9H-purine
9H-Purine, 9-(2-O-acetyl-5-O-benzoyl-3-deoxy-β-D-erythro-pentofuranosyl)-6-chloro-

Biological Activity

[Description]:

9-(2'-O-Acetyl-5'-O-benzoyl-3'-deoxy-beta-D-ribofuranosyl)-6-chloropurine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
592.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H17ClN4O5

[ Molecular Weight ]:
416.82

[ Flash Point ]:
312.0±32.9 °C

[ Exact Mass ]:
416.088745

[ LogP ]:
2.60

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.686

Related Compounds