2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)-

Names

[ Name ]:
2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)-

[Synonym ]:
N4-methyl-arabinofuranosyl-cytidine

Biological Activity

[Description]:

N4-Methylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₅N₃O₅

[ Molecular Weight ]:
257.24

[ Exact Mass ]:
257.10100

[ PSA ]:
120.33000

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(methylamino)-

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds