VPC-70063
Names
[ CAS No. ]:
13571-44-3
[ Name ]:
VPC-70063
Biological Activity
[Description]:
VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer[1].
[Related Catalog]:
[Target]
IC50: 8.9 μM (Myc-Max)[1]
[In Vitro]
VPC-70063 (25 μM; 96 h) shows Myc-Max transcriptional activity inhibition of 106% and Myc-Max/UBE2C downstream pathway inhibition of 94%[1]. VPC-70063 (6.25-25 μM, 48 h) causes apoptosis of LNCaP cells as indicated by cleavage of PARP[1]. VPC-70063 (0-500 μM; 0-600 s) disrupts the interaction of Myc-Max with DNA in a dose dependent manner[1]. Western Blot Analysis[1] Cell Line: LNCaP cells Concentration: 6.25 μM, 12.5 μM and 25 μM Incubation Time: 48 h Result: Induced PARP cleavage.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C16H12F6N2S
[ Molecular Weight ]:
378.34