T2AA

Names

[ Name ]:
T2AA

[Synonym ]:
4-{4-[(2S)-2-Amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol
Benzenepropanol, β-amino-4-(4-hydroxyphenoxy)-3,5-diiodo-, (βS)-

Biological Activity

[Description]:

T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

T2AA(15 μM, 72 h) 抑制链间 DNA 交联（ICL）修复，它可以阻止作为 ICL 修复中间体形成的 DNA 双链断裂（DSB）的分解，具有抑制 DSB 修复的能力[1]。

[References]

[1]. Akira Inoue, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014 Mar 7;289(10):7109-7120.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
568.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₅I₂NO₃

[ Molecular Weight ]:
511.093

[ Flash Point ]:
297.4±30.1 °C

[ Exact Mass ]:
510.914124

[ LogP ]:
3.44

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.715