Cinnamic acid

Names

[ CAS No. ]:
140-10-3

[ Name ]:
Cinnamic acid

[Synonym ]:
trans-3-Phenylacrylic acid,Cinnamic acid
trans-Cinnamic acid
Cinnamic acid
(2E)-3-Phenylacrylic acid
EINECS 205-398-1
MFCD00004369
trans-3-Phenylacrylic Acid
Cinnamyl acid

Biological Activity

[Description]:

trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

Natural Products >> Phenylpropanoids

[Target]

Bacterial[1]

[In Vitro]

trans-Cinnamic acid is an antimicrobial activity, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1. trans-cinnamic acid shows moderate inhibition on the rainbow trout intestinal isolates A. sobria SY-AS3 and S. baltica, SY-S145, gill isolate F. spartansii SY-FS1 and fish pathogens A. salmonicida ATCC 33658, Listonella anguillarum, SY-L24, V. crassostreae SY-VC10 and Y. ruckeri E42. trans-cinnamic acid is more effective on bacteria when the pH of the culture media is not neutralized[1].

[References]

[1]. Yilmaz S, et al. Antimicrobial activity of trans-cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates. J Appl Microbiol. 2018 Sep 4.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
265.0±0.0 °C at 760 mmHg

[ Melting Point ]:
133 °C(lit.)

[ Molecular Formula ]:
C₉H₈O₂

[ Molecular Weight ]:
148.159

[ Flash Point ]:
189.5±9.6 °C

[ Exact Mass ]:
148.052429

[ PSA ]:
37.30000

[ LogP ]:
2.41

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.616

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
0.4 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD7850000

CHEMICAL NAME :: Cinnamic acid, (E)-

CAS REGISTRY NUMBER :: 140-10-3

BEILSTEIN REFERENCE NO. :: 1905952

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H8-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
GD7850000

[ HS Code ]:
29163900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29163900

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