hSMG-1 inhibitor 11j
Names
[ CAS No. ]:
1402452-15-6
[ Name ]:
hSMG-1 inhibitor 11j
[Synonym ]:
compound 11j [PMID: 23021994]
2-Chloro-N,N-diethyl-5-{[4-(2-{4-[(methylcarbamoyl)amino]phenyl}-4-pyridinyl)-2-pyrimidinyl]amino}benzenesulfonamide
Benzenesulfonamide, 2-chloro-N,N-diethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-
Biological Activity
[Description]:
[Related Catalog]:
[Target]
hSMG-1:0.11 nM (IC50)
mTOR:50 nM (IC50)
PI3Kγ:60 nM (IC50)
PI3Kα:92 nM (IC50)
GSKα:260 (IC50)
GSKβ:330 (IC50)
CDK2:7.1 μM (IC50)
CDK1:32 μM (IC50)
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Molecular Formula ]:
C27H28ClN7O3S
[ Molecular Weight ]:
566.074
[ Exact Mass ]:
565.166260
[ LogP ]:
4.38
[ Index of Refraction ]:
1.640