Oligomycin

Names

[ Name ]:
Oligomycin

[Synonym ]:
Oligomycin From Streptomyces Diastatochromogenes
EINECS 215-767-9
MFCD00065705

Biological Activity

[Description]:

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F1FO ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins will reduce ATP depletion rather than block ATP synthesis.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase

Chemical & Physical Properties

[ Density]:
1.14 g/cm3

[ Boiling Point ]:
886.3ºC at 760 mmHg

[ Melting Point ]:
84-100ºC

[ Molecular Formula ]:
C₁₃₅H₂₂₀O₃₃

[ Molecular Weight ]:
2371.171

[ Flash Point ]:
252ºC

[ Exact Mass ]:
2369.553711

[ PSA ]:
536.99000

[ LogP ]:
17.71190

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.543

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Sparingly soluble in water. Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RK3325000

CHEMICAL NAME :: Oligomycin

CAS REGISTRY NUMBER :: 1404-19-9

LAST UPDATED :: 199012

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 15,660,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
24/25

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
RK3325000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

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