NSC 625987
Names
[ CAS No. ]:
141992-47-4
[ Name ]:
NSC 625987
[Synonym ]:
1,4-Dimethoxy-9-thio(10H)-acridone
Tocris-2152
Biological Activity
[Description]:
NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].
[Related Catalog]:
[Target]
CDK4/D1:0.2 μM (IC50)
[In Vitro]
NSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%[2].
[References]
Chemical & Physical Properties
[ Density]:
1.32g/cm3
[ Boiling Point ]:
460.4ºC at 760 mmHg
[ Molecular Formula ]:
C15H13NO2S
[ Molecular Weight ]:
271.33400
[ Flash Point ]:
232.2ºC
[ Exact Mass ]:
271.06700
[ PSA ]:
66.34000
[ LogP ]:
4.06780
[ Vapour Pressure ]:
1.17E-08mmHg at 25°C
[ Index of Refraction ]:
1.683