5'-Deoxy-5'-iodouridine

Names

[ Name ]:
5'-Deoxy-5'-iodouridine

[Synonym ]:
5'-iodo-5'-deoxy-uridine
5'-Jod-5'-desoxy-uridin
Uridine,5'-deoxy-5'-iodo
5'-Iodo-2'deoxyuridine
5'-deoxy-5'-iodouridine

Biological Activity

[Description]:

5'-Deoxy-5'-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.118g/cm3

[ Molecular Formula ]:
C₉H₁₁IN₂O₅

[ Molecular Weight ]:
354.10

[ Exact Mass ]:
353.97100

[ PSA ]:
104.81000

[ Index of Refraction ]:
1.694

Safety Information

[ Hazard Codes ]:
Xn

5'-Deoxy-5'-iodouridine

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds