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4-N-benzoylgeMcitabine

Names

[ CAS No. ]:
142816-70-4

[ Name ]:
4-N-benzoylgeMcitabine

[Synonym ]:
N-benzoyl-2'-deoxy-2',2'-difluorocytidine
4-N-benzoylgemcitabine
N-benzoyl-2'-deoxy-2',2'-difluorocytidine hydrochloride
N-Bz-Gemcitabine

Biological Activity

[Description]:

N4-Benzoyl-2’-deoxy-2’,2’-diflurocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C16H15F2N3O5

[ Molecular Weight ]:
367.30

[ Exact Mass ]:
367.09800

[ PSA ]:
113.68000

[ LogP ]:
0.45450

Related Compounds