JAK3-IN-12

Names

[ CAS No. ]:
1430095-86-5

[ Name ]:
JAK3-IN-12

Biological Activity

[Description]:

JAK3-IN-12 (compound 15k) is a highly potent JAK3 inhibitor with an IC50 value of 9.5 nM. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Research Areas >> Inflammation/Immunology

[Target]

JAK3:9.5 nM (IC50)


[In Vivo]

Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice[1]. IV (1 mg/kg); PO (3 mg/kg) Tmax (h) 0.5 Cmax (ng/ml) 146±48 tmax (h) 1.85±0.43 CL (mL/min/kg), iv 40.37 ± 3.61 AUC0-α (μg/mL·h) 192 ± 56 F (%) 15

[References]

[1]. Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H19N5O4S

[ Molecular Weight ]:
413.45

Related Compounds