Adenosine,5'-amino-5'-deoxy-

Names

[ Name ]:
Adenosine,5'-amino-5'-deoxy-

[Synonym ]:
5'-amino-5'-deoxyAdo
5-amino-5-deoxyadenosine
5'-AMINO-5'-DEOXY-D-ADENOSINE
5'-Deoxy-5'-aminoadenosine
5'-amino-2',3'-O-isopropylidene-5'-deoxyadenosine
5'-NH-ADO
Adenosine,5'-aMino-5'-deoxy

Biological Activity

[Description]:

5'-Amino-5'-deoxyadenosine (NH2dAdo; Nsc 238990) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.08 g/cm3

[ Boiling Point ]:
647.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₄N₆O₃

[ Molecular Weight ]:
266.26

[ Flash Point ]:
345.4ºC

[ Exact Mass ]:
266.11300

[ PSA ]:
145.33000

[ Vapour Pressure ]:
1.18E-17mmHg at 25°C

[ Index of Refraction ]:
1.935

Adenosine,5'-amino-5'-deoxy-

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds