9-(2-Deoxy-β-L-Ribofuranosyl)Adenine

Names

[ Name ]:
9-(2-Deoxy-β-L-Ribofuranosyl)Adenine

[Synonym ]:
2'-desoxyadenosine
2'-Desoxy-adenosin
2'-deoxy-adenosine

Biological Activity

[Description]:

2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

[In Vitro]

2'-Deoxy-L-adenosine shows anti-hepadnavirus activity, withour affecting the replication of 15 other RNA and DNA viruses, neither nor inhibiting human DNA polymerases (α, β, and γ) or compromise mitochondrial function[1].

[In Vivo]

2'-Deoxy-L-adenosine (p.o.; once daily) reduces viral load by as much as 108 genome equivalent/mL serum without drug-related toxicity in woodchuck efficacy model of chronic HBV infection[1].

Chemical & Physical Properties

[ Density]:
1.91g/cm3

[ Boiling Point ]:
627.2ºC at 760 mmHg

[ Melting Point ]:
186-187ºC

[ Molecular Formula ]:
C₁₀H₁₃N₅O₃

[ Molecular Weight ]:
251.24200

[ Flash Point ]:
333.1ºC

[ Exact Mass ]:
251.10200

[ PSA ]:
119.31000

[ Vapour Pressure ]:
1.36E-16mmHg at 25°C

[ Index of Refraction ]:
1.863

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%