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Murrayanol

Names

[ CAS No. ]:
144525-81-5

[ Name ]:
Murrayanol

[Synonym ]:
1-((E)-3,7-Dimethyl-octa-2,6-dienyl)-7-methoxy-6-methyl-9H-carbazol-2-ol

Biological Activity

[Description]:

Murrayanol is a natural carbazole alkaloid with a variety of biological activities. Murrayanol shows anti-inflammatory, topoisomerase I and topoisomerase II (Topoisomerase) inhibition activities. Murrayanol also as a mosquitocidal and antimicrobial[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Murrayanol (Compound 2) 在抗炎试验中对人前列腺素 H 合酶同工酶 1 (hPGHS-1) 的 IC50 为 109 μg/mL，对 hPGHS-2 的 IC50 为 218 μg/mL[1]。 Murrayanol (Compound 2) 在 12.5 µg/mL 浓度下对埃及伊蚊显示 100% 的死亡率[1]。 当对酿酒酵母突变菌株进行测试时，Murrayanol (Compound 2) 在 50 µg/mL 浓度下完全抑制拓扑异构酶 I 和 II 活性[1]。 Murrayanol (Compound 2) 对克氏梭菌和大肠杆菌的 MIC1000 为 100 µg/mL，但对金黄色葡萄球菌和化脓性链球菌的 MIC100 为 25 µg/mL[1]。

[References]

[1]. R S Ramsewak, et al. Biologically active carbazole alkaloids from Murraya koenigii. J Agric Food Chem. 1999 Feb;47(2):444-7.  

Chemical & Physical Properties

[ Density]:
1.113±0.06 g/cm3(Predicted)

[ Boiling Point ]:
570.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H29NO2

[ Molecular Weight ]:
363.49300

[ Exact Mass ]:
363.22000

[ PSA ]:
45.25000

[ LogP ]:
6.57890

Related Compounds