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Oosponol

Names

[ CAS No. ]:
146-04-3

[ Name ]:
Oosponol

[Synonym ]:
4-glycoloyl-8-hydroxy-1H-isochromen-1-one
Lezitin=Oosponol
Lenzitin
8-Hydroxy-4-(hydroxyacetyl)-1H-2-benzopyran-1-one
ISOCOUMARIN,4-GLYCOLYL-8-HYDROXY
8-hydroxy-4-hydroxyacetyl-isochromen-1-one
Oosponol
4-Glycolyl-8-hydroxy-isocoumarin

Biological Activity

[Description]:

Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Umezawa H, et al.. Dopamine -hydroxylase inhibitor produced by Gloeophyllum striatum and its identity with oosponol. J Antibiot (Tokyo). 1972 Apr;25(4):239-42.  

[2]. Sonnenbichler J,et al. Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells. Eur J Biochem. 1997 May 15;246(1):45-9.  

Chemical & Physical Properties

[ Density]:
1.547g/cm3

[ Boiling Point ]:
485.9ºC at 760mmHg

[ Molecular Formula ]:
C11H8O5

[ Molecular Weight ]:
220.18

[ Flash Point ]:
198.9ºC

[ Exact Mass ]:
220.03700

[ PSA ]:
87.74000

[ LogP ]:
0.67360

[ Vapour Pressure ]:
2.96E-10mmHg at 25°C

[ Index of Refraction ]:
1.657

Related Compounds