Cysteamine Hydrochloride

Names

[ CAS No. ]:
156-57-0

[ Name ]:
Cysteamine Hydrochloride

[Synonym ]:
2-AMino&CYSTEAMINE HCL
1-Amino-2-mercaptoethane hydrochloride
2-aminoethylmercaptan hydrochloride
2-Mercapto ethyl amine hydrochloride
EINECS 205-858-1
β-Mercapto ethylamine hydrochloride
CYSTEAMINE HCL SOLID
Cysteinamine Hydrochloride
thiol hydrochloride
2-Mercaptoethylamine hydrochloride
Cysteamine Hydrochloride
2-Aminoethanethiol hydrochloride (1:1)
Cysteamine (Hydrochloride)
2-Aminoethanethiol Hydrochloride
Thioethanolamine hydrochloride
2-Mercaptoethanamine Hydrochloride
CYSTEAMINIUM CHLORIDE
2-Mercaptoethylamin
2-amino-ethanethiol hydrochloride
1-Aminoethane-2-thiol hydrochloride
Cysteamine HCl
mea hydrochloride
b-Mercaptoethylamine Hydrochloride
2-Amino-ethanethiol.HCl
Ethanethiol, 2-amino-, hydrochloride (1:1)
β-Mercaptoethylamine hydrochloride
MFCD00012904
Decarboxycysteine hydrochloride
2-Amino-ethanethiol;hydrochloride
2-Mercaptoethylammonium chloride
Aminoethanethiol hydrochloride

Biological Activity

[Description]:

Cysteamine Hydrochloride is an agent for the treatment of nephropathic cystinosis and an antioxidant.Target: OthersCysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2].

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Metabolic Disease

[References]

[1]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.

[2]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.75

[ Boiling Point ]:
116.4ºC at 760 mmHg

[ Melting Point ]:
67-71 °C

[ Molecular Formula ]:
C₂H₈ClNS

[ Molecular Weight ]:
113.610

[ Flash Point ]:
24.2ºC

[ Exact Mass ]:
113.006599

[ PSA ]:
64.82000

[ LogP ]:
1.37720

[ Vapour Pressure ]:
16.7mmHg at 25°C

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable, but hygroscopic. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
VERY SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ0200000

CHEMICAL NAME :: Ethanethiol, 2-amino-, hydrochloride

CAS REGISTRY NUMBER :: 156-57-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C2-H7-N-S.Cl-H

MOLECULAR WEIGHT :: 113.62

WISWESSER LINE NOTATION :: Z2SH &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1352 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 244 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 5 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 153,57,1985

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S36/37/39-S26

[ RIDADR ]:
UN 3335

[ WGK Germany ]:
3

[ RTECS ]:
KJ0200000

[ HS Code ]:
2921199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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