zoxamide

Names

[ Name ]:
zoxamide

[Synonym ]:
3,5-Dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide
N-[3'-(1'-chloro-3'-methyl-2'-oxopentan)]-3,5-dichloro-4-methylbenzamide
rac-3,5-dichloro-N-[(3R)-1-chloro-3-methyl-2-oxopentan-3-yl]-4-methylbenzamide
3,5-Dichloro-N-(1-chloro-3-methyl-2-oxo-3-pentanyl)-4-methylbenzamide
3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxo-propyl)-4-methyl-benzamide
zoxamide
Zoxamid
3,5-Dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-p-toluamide
3,5-dichloro-N-(3-chloro-l-ethyl-l-methyl-2-oxopropyl)-4-methylbenzamide
(S)-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-3.5-dichloro-4-methylbenzamide
Zoxium
rh-7281
3,5-Dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzamide
Benzamide, 3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methyl-
(RS)-3,5-Dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-p-toluamide
N-(1-chloro-3-methyl-2-oxopent-3-yl)-3,5-dichloro-4-methylbenzamide

Biological Activity

[Description]:

Zoxamide (RH-7281) is an oomycete fungicide. Zoxamide arrests nuclear division in Phytophthora capsici germlings and destroyed the microtubule cytoskeleton[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Mei X, et al. Proteomic analysis on zoxamide-induced sensitivity changes in Phytophthora cactorum. Pestic Biochem Physiol. 2015 Sep;123:9-18.

[2]. David H. Young, et al. Mode of Action of Zoxamide (RH-7281), a New Oomycete Fungicide. Pesticide Biochemistry and Physiology. Volume 69, Issue 2, February 2001, Pages 100-111.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
415.4±45.0 °C at 760 mmHg

[ Melting Point ]:
159.5-161ºC

[ Molecular Formula ]:
C₁₄H₁₆Cl₃NO₂

[ Molecular Weight ]:
336.64

[ Flash Point ]:
205.0±28.7 °C

[ Exact Mass ]:
335.024658

[ PSA ]:
46.17000

[ LogP ]:
4.84

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.545

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H319-H410

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P333 + P313-P391-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Simultaneous determination of sixteen amide fungicides in vegetables and fruits by dispersive solid phase extraction and liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 989 , 11-20, (2015)

A modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method using multi-walled carbon nanotubes (MWCNTs) as a reversed-dispersive solid phase extraction (r-dSPE) material combined wit...

Resistance to the novel fungicide pyrimorph in Phytophthora capsici: risk assessment and detection of point mutations in CesA3 that confer resistance.

PLoS ONE 8 , e56513, (2013)

Pyrimorph is a novel fungicide with high activity against the plant pathogen Phytophthora capsici. We investigated the risk that P. capsici can develop resistance to pyrimorph. The baseline sensitivit...